The Twin City Future Innovation Manufacturing Hub (2CFIMH) is a cross-border initiative fostering innovation, collaboration, and sustainable growth in the manufacturing sector between Austria and Slovakia. Bringing together industry leaders, academia, government, and civil society, the project aims to develop future-proof strategies, support startups, enhance workforce skills, and drive co-creation. Through exploratory missions, pilot programmes, and strategic recommendations, 2CFIMH paves the way for a resilient and competitive manufacturing ecosystem in the Twin City region.